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Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities

Authors :
Ruirui Yu
Xiaojian Li
Peng Yi
Ping Wen
Shuhong Wang
Chenghui Liao
Xun Song
Haiqiang Wu
Zhendan He
Chenyang Li
Source :
Molecules, Vol 28, Iss 21, p 7321 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

This study explores the antifungal properties of Agaricus blazei Murrill, a valuable medicinal and edible fungus. Six compounds (1–6) were first isolated from A. blazei using various isolation techniques and identified using spectroscopic methods. These compounds include linoleic acid, 1,1′-oxybis(2,4-di-tert-butylbenzene), glycerol monolinoleate, volemolide (17R)-17-methylincisterol, (24s)-ergosta-7-en-3-ol, and dibutyl phthalate. This study also assesses the antifungal activities of these compounds against Trichophyton mentagrophology, Trichophyton rubrum, Candida albicans, and Cryptococcus neoformans. The results demonstrate varied sensitivities against these pathogenic fungi, with compound 2 showing significant inhibition against T. mentagrophology, compound 3 showing significant inhibition against T. rubrum, and compound 6 showing significant inhibition against C. albicans. This study underscores the medicinal potential of A. blazei as an antifungal agent and sheds light on its valuable research implications.

Details

Language :
English
ISSN :
14203049
Volume :
28
Issue :
21
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.46d1aee33ba443ccb839c6d585d70e13
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules28217321