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Targeted Drug-Resistance Testing Strategy for Multidrug-Resistant Tuberculosis Detection, Lima, Peru, 2005–2008

Authors :
Gustavo E. Velásquez
Martin Yagui
J. Peter Cegielski
Luis Asencios
Jaime Bayona
Cesar Bonilla
Hector O. Jave
Gloria Yale
Carmen Suárez
Sidney Atwood
Carmen C. Contreras
Sonya S. Shin
Source :
Emerging Infectious Diseases, Vol 17, Iss 3, Pp 432-440 (2011)
Publication Year :
2011
Publisher :
Centers for Disease Control and Prevention, 2011.

Abstract

The Peruvian National Tuberculosis Control Program issued guidelines in 2006 specifying criteria for culture and drug-susceptibility testing (DST), including district-level rapid DST. All patients referred for culture and DST in 2 districts of Lima, Peru, during January 2005–November 2008 were monitored prospectively. Of 1,846 patients, 1,241 (67.2%) had complete DST results for isoniazid and rifampin; 419 (33.8%) patients had multidrug-resistant (MDR) TB at the time of referral. Among patients with new smear-positive TB, household contact and suspected category I failure were associated with MDR TB, compared with concurrent regional surveillance data. Among previously treated patients with smear-positive TB, adult household contact, suspected category II failure, early relapse after category I, and multiple previous TB treatments were associated with MDR TB, compared with concurrent regional surveillance data. The proportion of MDR TB detected by using guidelines was higher than that detected by a concurrent national drug-resistance survey, indicating that the strategy effectively identified patients for DST.

Details

Language :
English
ISSN :
10806040 and 10806059
Volume :
17
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Emerging Infectious Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.46bca436add040bdba06a08616e7b898
Document Type :
article
Full Text :
https://doi.org/10.3201/eid1703.101553