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Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin
- Source :
- Cell Adhesion & Migration, Vol 13, Iss 1, Pp 121-138 (2019)
- Publication Year :
- 2019
- Publisher :
- Taylor & Francis Group, 2019.
-
Abstract
- The function of small G protein signalling modulators (SGSM1/2/3) in cancer remains unknown. Our findings demonstrated that SGSM2 is a plasma membrane protein that strongly interacted with E-cadherin/β-catenin. SGSM2 downregulation enhanced the phosphorylation of focal adhesion kinase (FAK; Y576/577), decreased the expression of epithelial markers such as E-cadherin, β-catenin, and Paxillin, and increased the expression of Snail and Twist-1, which reduced cell adhesion and promoted cancer cell migration. Oestrogen and fibronectin treatment was found to promote the colocalization of SGSM2 at the leading edge with phospho-FAK (Y397). The BioGRID database showed that SGSM2 potentially interacts with cytoskeleton remodelling and cell-cell junction proteins. These evidences suggest that SGSM2 plays a role in modulating cell adhesion and cytoskeleton dynamics during cancer migration.
- Subjects :
- sgsm
breast cancer
cell adhesion
e-cadherin
oestrogen receptor
emt
Cytology
QH573-671
Subjects
Details
- Language :
- English
- ISSN :
- 19336918 and 19336926
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Cell Adhesion & Migration
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.46865f48a6b342c4a92b3927f29245c7
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/19336918.2019.1568139