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Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3

Authors :
Keisuke Sanematsu
Masato Yamamoto
Yuki Nagasato
Yuko Kawabata
Yu Watanabe
Shusuke Iwata
Shingo Takai
Kiyoshi Toko
Toshiro Matsui
Naohisa Wada
Noriatsu Shigemura
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Molecular dynamics simulations and functional assays of the transmembrane domain of the sweet taste receptor subunit, TAS1R3 reveal mechanisms on the allostery of sweet receptor activation or inactivation and pH-dependent sensitivity to saccharin.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.46650d6086da41119a00c18ee33b4864
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-023-04705-5