The Mediating Effect of Symptom Burden in the Depression and Quality of Life in Patients with Maintenance Hemodialysis

Ning-ning Xia, Kuei-ching Pan, Jing Liu, Daxi Ji Department of Nephrology, Nanjing BenQ Medical Center, BenQ Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province, People’s Republic of ChinaCorrespondence: Kuei-ching Pan; Jing Liu, Email PKJ13951672501@126.com; liujing66382@126.comObjective: To investigate current status of quality of life and the association between depression and symptom burden in a sample of Chinese maintenance hemodialysis (MHD) patients.Methods: A self-designed patient general information questionnaire, disease-related information questionnaire, dialysis patient symptom burden scale, depression scale, and quality of survival scale were used to investigate 380 maintenance haemodialysis patients in haemodialysis centres. A regression model of the factors affecting the quality of survival was established using structural equation modelling.Results: The regression model data had a high goodness of fit: c2/df = 4.736, RMSEA = 0.099, GFI = 0.918, CFI = 0.972, TLI = 0.962, SRMR = 0.0469. Structural equation model analysis showed that depression had a positive predictive effect on symptom burden, β = 0.398, P