Immunohistochemical profile in estimation of biological properties and prognosis of breast cancer

The prognostic value of markers of biological properties of breast cancer (BC), their age-dependent and mutual correlations are finally not determined. The purpose of our study was to determine the dependence of expression of prognostic markers (ER, PgR, HER-2/neu, pS2, р53, VEGF, Кі-67, bcl-2) on age and presence of metastases at BC in women, to find the cross-correlations in groups with and without metastases. From data of statistical analysis (criterion of χ2), all of markers are thought to be used as prognostic of metastasis risk with the high level of reliability at patients of different age. The exceptions were ER and PgR in group before 35 years, ER - in group 35-50 years. Only for the ER and PgR an increase of expression with age was observed: for expression of ER a difference was reliable in groups 35-50 and above 50 years, in groups before 35 years and after 50 years; for PgR - between groups 35-50 years and above 50 years. The expression of markers of р53 and Кі-67 showed the reliable difference in groups with the presence of metastases, regardless of age. The last are most reliable as prognostic for the group before 35 years. Cross-correlations between expression of markers which depended on age and/or metastasis were determined.