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Application of 'Click' chemistry in solid phase synthesis of alkyl halides

Authors :
Lalthazuala Rokhum
Diparjun Das
Tridib Chanda
Source :
Acta Chimica Slovenica, Vol 62, Iss 4, Pp 775-783 (2015)
Publication Year :
2015
Publisher :
Slovenian Chemical Society, 2015.

Abstract

A convenient and highly selective microwave assisted procedure for the conversion of allylic, benzylic and aliphatic alcohols to their corresponding halide using polymer-bound triphenylphosphine and iodine is presented. In case of symmetrical diols, mono-iodination product is obtained in very high yield. Additionally, high regioselective behavior is observed in our procedure. Simplicity in operation, no column chromatography requirement for purification of the product, recyclability of the reagents used, short reaction times and good to excellent yields are the advantages of our protocol. Most functional groups remain unaffected under our reaction condition.

Details

Language :
English
ISSN :
13180207 and 15803155
Volume :
62
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Acta Chimica Slovenica
Publication Type :
Academic Journal
Accession number :
edsdoj.460a472d37b4b649cb7d7bcecd97143
Document Type :
article
Full Text :
https://doi.org/10.17344/acsi.2015.1478