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Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils

Authors :
Ruiming Zhao
Hui Dai
Rodolfo J. Arias
Gerardo A. De Blas
Gerardo Orta
Martín A. Pavarotti
Rong Shen
Eduardo Perozo
Luis S. Mayorga
Alberto Darszon
Steve A. N. Goldstein
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

The human voltage-gated proton channel (hHv1) maintains intracellular pH and membrane potential in sperm and neutrophils. Here, the authors show that albumin activates hHv1, by binding to the channel voltage sensor domains to enhance open probability and increases proton current, and that activation is required to trigger sperm to allow oocyte fertilization and to sustain production and release of immune inflammatory mediators during the neutrophil respiratory burst.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.46008eddc1543f7b537b4b7900693ee
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-24145-1