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Severe complications of nivolumab monotherapy in an adolescent with malignant melanoma
- Source :
- Central European Journal of Immunology, Vol 48, Iss 3, Pp 251-256 (2023)
- Publication Year :
- 2023
- Publisher :
- Termedia Publishing House, 2023.
-
Abstract
- This study presents a case of a 17-year-old female patient who had previously undergone surgical resection of melanoma in the right periscapular area. She was administered adjuvant treatment with the PD-1 inhibitor nivolumab as monotherapy. The mechanism of action of this drug is based on increased stimulation of the immune system. The patient developed a series of complications including capillary leak syndrome and hypothyroidism after the fifth cycle of therapy, as a result of dysregulation of immunity. Nivolumab treatment had to be discontinued and glucocorticosteroids were administered as a salvage therapy. After several months, two relapses developed in the subcutaneous tissue – first in the left and then in the right iliac region, confirmed as distant metastases of malignant melanoma, treated with resections of the lesions and intensity-modulated radiation therapy. Follow-up imaging studies and clinical examinations showed no metastases or pathologically enlarged lymph nodes.
- Subjects :
- melanoma
hypothyroidism
nivolumab
capillary leak syndrome
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 14263912 and 16444124
- Volume :
- 48
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Central European Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4595000100a34fafa64bfb052c55feb8
- Document Type :
- article
- Full Text :
- https://doi.org/10.5114/ceji.2023.130864