The role of vitamin C in the prevention of pancreatic cancer: a systematic-review

Introduction and aimThe aim of this systematic review was to assess the role of vitamin C in the prevention of pancreatic cancer (PC).MethodsA comprehensive literature search was performed in PubMed, Embase and Web of Science up to August 2023, to identify randomized controlled trials (RCT), cohort studies and mendelian randomization studies based on prospective databases assessing the role of vitamin C in PC prevention.ResultsA total of twelve studies including European and North-American participants were included: two RCT, three mendelian randomization (MR) studies and seven cohort studies. Both RCT showed high quality in Cochrane risk of bias tool. Only one cohort study had