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Pulmonary tuberculosis and lung cancer: simultaneous and sequential occurrence

Authors :
Denise Rossato Silva
Dirceu Felipe Valentini Junior
Alice Manica Muller
Carlos Podalirio Borges de Almeida
Paulo de Tarso Roth Dalcin
Source :
Jornal Brasileiro de Pneumologia, Vol 39, Iss 4, Pp 484-489 (2013)
Publication Year :
2013
Publisher :
Sociedade Brasileira de Pneumologia e Tisiologia, 2013.

Abstract

OBJECTIVE: Lung cancer (LC) is the leading cause of cancer-related death and represents a major public health problem worldwide. Another major cause of morbidity and mortality, especially in developing countries, is tuberculosis. The simultaneous or sequential occurrence of pulmonary tuberculosis and LC in the same patient has been reported in various case series and case-control studies. The objective of this study was to describe the characteristics of patients developing tuberculosis and LC, either simultaneously or sequentially. METHODS: This was a cross-sectional study based on the review of medical charts. RESULTS: The study involved 24 patients diagnosed with tuberculosis and LC between 2009 and 2012. The diagnoses of tuberculosis and LC occurred simultaneously in 10 patients, whereas tuberculosis was diagnosed prior to LC in 14. The median time between the two diagnoses was 5 years (interquartile range: 1-30 years). Fourteen patients (58.3%) were male, 20 (83.3%) were White, and 22 (91.7%) were smokers or former smokers. The most common histological type was adenocarcinoma, identified in 14 cases (58.3%), followed by epidermoid carcinoma, identified in 6 (25.0%). Seven patients (29.2%) presented with distant metastases at diagnosis; of those 7 patients, 5 (71%) were diagnosed with LC and tuberculosis simultaneously. CONCLUSIONS: In the present study, most of the patients with tuberculosis and LC were smokers or former smokers, and tuberculosis was diagnosed either before or simultaneously with LC. Non-small cell lung cancer, especially adenocarcinoma, was the most common histological type.

Details

Language :
English, Portuguese
ISSN :
18063756 and 18063713
Volume :
39
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Jornal Brasileiro de Pneumologia
Publication Type :
Academic Journal
Accession number :
edsdoj.4573a06f0fa54866b174cf2547018804
Document Type :
article
Full Text :
https://doi.org/10.1590/S1806-37132013000400013