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Accumbal Dopamine Responses Are Distinct between Female Rats with Active and Passive Coping Strategies

Authors :
Vsevolod V. Nemets
Ekaterina P. Vinogradova
Vladislav Zavialov
Vladimir P. Grinevich
Evgeny A. Budygin
Raul R. Gainetdinov
Source :
Biomolecules, Vol 14, Iss 10, p 1280 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

There is a gap in existing knowledge of stress-triggered neurochemical and behavioral adaptations in females. This study was designed to explore the short-term consequences of a single social defeat (SD) on accumbal dopamine (DA) dynamics and related behaviors in female Wistar rats. During the SD procedure, rats demonstrated different stress-handling strategies, which were defined as active and passive coping. The “active” subjects expressed a significantly higher level of activity directed toward handling stress experience, while the “passive” ones showed an escalated freezing pattern. Remarkably, these opposite behavioral manifestations were negatively correlated. Twenty-four hours following the SD exposure, decreased immobility latency in the Porsolt test and cognitive augmentation in the new object recognition evaluation were evident, along with an increase in electrically evoked mesolimbic DA release in passive coping rats. Rats exhibiting an active pattern of responses showed insignificant changes in immobility and cognitive performance as well as in evoked mesolimbic DA response. Furthermore, the dynamics of the decline and recovery of DA efflux under the depletion protocol were significantly altered in the passive but not active female rats. Taken together, these data suggest that female rats with a passive coping strategy are more susceptible to developing behavioral and neurochemical alterations within 24 h after stress exposure. This observation may represent both maladaptive and protective responses of an organism on a short timescale.

Details

Language :
English
ISSN :
2218273X
Volume :
14
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Biomolecules
Publication Type :
Academic Journal
Accession number :
edsdoj.45507862d5554f46a5f0581f5a9d67a2
Document Type :
article
Full Text :
https://doi.org/10.3390/biom14101280