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Modality for estimating NMR relaxation time using perturbed angular correlation in double-photon emission nuclides

Authors :
Wataru Matsumoto
Boyu Feng
Yoshiki Tamai
Taisei Ueki
Kei Kamada
Mizuki Uenomachi
Hideki Tomita
Motofumi Fushimi
Kenji Shimazoe
Hiroyuki Takahashi
Masaki Sekino
Source :
AIP Advances, Vol 14, Iss 1, Pp 015217-015217-5 (2024)
Publication Year :
2024
Publisher :
AIP Publishing LLC, 2024.

Abstract

T2 relaxation time in magnetic resonance imaging (MRI), which is determined by magnetic dipole interactions, has been employed as a parameter for tumor detection. However, owing to the lack of MRI detection sensitivity, nuclear medicine imaging is currently the basic option for tracking low concentrations of chemical probes. Previous studies utilizing cascade radionuclides have focused on the relaxation due to electric quadrupole interactions. However, magnetic dipole interactions, which are crucial in MRI, remains to be elucidated. In this study, we determined the magnetic relaxation rate by using 111In, a cascade radionuclide used in clinical single-photon emission computed tomography (SPECT) scans. As the angle between the gamma rays from the nuclei is affected by the electrical and magnetic interactions acting on the nuclei, we measured the angular correlation ratio by using eight gadolinium gallium garnet (GAGG) multi-pixel photon counter (MPPC) 8 × 8 array detectors and extracted the magnetic relaxation rate. Consequently, we obtained a rate that increased with the Fe concentration, similar to the T2 relaxation rate, although it was influenced by the inhomogeneity of the external magnetic field. This study utilized low concentrations of the liquid-state radionuclide, which is commonly used in clinical nuclear medicine imaging scans and is expected to provide much higher sensitivity and more selective detection of tumors than conventional MRI.

Subjects

Subjects :
Physics
QC1-999

Details

Language :
English
ISSN :
21583226
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
AIP Advances
Publication Type :
Academic Journal
Accession number :
edsdoj.453af919f0024e82b1f313acc46660f4
Document Type :
article
Full Text :
https://doi.org/10.1063/9.0000665