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Microangiopathic Hemolytic Anemia as a Paraneoplastic Syndrome in a Patient with Metastatic Gastric Cancer

Authors :
Shahd T Natsheh
Tuqa Abu Ihlayel
Rawda Qasrawi
Qusai A Alsalah
Ahmad G Hammouri
Amer Zughayyer
Hasan Arafat
Source :
Clinical Medicine Insights: Case Reports, Vol 17 (2024)
Publication Year :
2024
Publisher :
SAGE Publishing, 2024.

Abstract

Cancer-associated microangiopathic hemolytic anemia (CA-MAHA) is a rare paraneoplastic syndrome. The most effective approach to treating CA-MAHA is to address the underlying malignancy. Documented cases of CA-MAHA are limited to fewer than 50 patients in the literature. Herein, we present a 51-year-old female patient who developed CA-MAHA as a complication of gastric adenocarcinoma. Despite receiving neoadjuvant and adjuvant chemotherapy for gastric cancer, the patient experienced disease progression with metastatic lesions in the liver, pancreas, and other sites. This report highlights the challenges in diagnosing and distinguishing CA-MAHA from other similar conditions such as disseminated intravascular coagulation (DIC), hemolytic uremic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP), and rheumatological paraneoplastic syndromes. Additionally, it concludes that CA-MAHA is associated with a poor prognosis and limited clinical benefit from treatment, emphasizing the need for early diagnosis and effective management strategies.

Subjects

Subjects :
Medicine (General)
R5-920

Details

Language :
English
ISSN :
11795476
Volume :
17
Database :
Directory of Open Access Journals
Journal :
Clinical Medicine Insights: Case Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.4518a198cc044e75a91137093ad48fb4
Document Type :
article
Full Text :
https://doi.org/10.1177/11795476241271534