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Key advances in vaccine development for tuberculosis—success and challenges

Key advances in vaccine development for tuberculosis—success and challenges

Authors :
Rocky Lai
Abiola F. Ogunsola
Tasfia Rakib
Samuel M. Behar
Source :
npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Abstract Breakthrough findings in the clinical and preclinical development of tuberculosis (TB) vaccines have galvanized the field and suggest, for the first time since the development of bacille Calmette-Guérin (BCG), that a novel and protective TB vaccine is on the horizon. Here we highlight the TB vaccines that are in the development pipeline and review the basis for optimism in both the clinical and preclinical space. We describe immune signatures that could act as immunological correlates of protection (CoP) to facilitate the development and comparison of vaccines. Finally, we discuss new animal models that are expected to more faithfully model the pathology and complex immune responses observed in human populations.

Details

Language :
English
ISSN :
20590105
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
npj Vaccines
Publication Type :
Academic Journal
Accession number :
edsdoj.45165aae2494116803121eb594e0bb8
Document Type :
article
Full Text :
https://doi.org/10.1038/s41541-023-00750-7