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The First 110,593 COVID-19 Patients Hospitalised in Lombardy: A Regionwide Analysis of Case Characteristics, Risk Factors and Clinical Outcomes

Authors :
Nicole Mauer
Greta Chiecca
Greta Carioli
Vincenza Gianfredi
Licia Iacoviello
Silvia Bertagnolio
Ranieri Guerra
Anna Odone
Carlo Signorelli
Source :
International Journal of Public Health, Vol 67 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

Objectives: To describe the monthly distribution of COVID-19 hospitalisations, deaths and case-fatality rates (CFR) in Lombardy (Italy) throughout 2020.Methods: We analysed de-identified hospitalisation data comprising all COVID-19-related admissions from 1 February 2020 to 31 December 2020. The overall survival (OS) from time of first hospitalisation was estimated using the Kaplan-Meier method. We estimated monthly CFRs and performed Cox regression models to measure the effects of potential predictors on OS.Results: Hospitalisation and death peaks occurred in March and November 2020. Patients aged ≥70 years had an up to 180 times higher risk of dying compared to younger patients [70–80: HR 58.10 (39.14–86.22); 80–90: 106.68 (71.01–160.27); ≥90: 180.96 (118.80–275.64)]. Risk of death was higher in patients with one or more comorbidities [1: HR 1.27 (95% CI 1.20–1.35); 2: 1.44 (1.33–1.55); ≥3: 1.73 (1.58–1.90)] and in those with specific conditions (hypertension, diabetes).Conclusion: Our data sheds light on the Italian pandemic scenario, uncovering mechanisms and gaps at regional health system level and, on a larger scale, adding to the body of knowledge needed to inform effective health service planning, delivery, and preparedness in times of crisis.

Details

Language :
English
ISSN :
16618564
Volume :
67
Database :
Directory of Open Access Journals
Journal :
International Journal of Public Health
Publication Type :
Academic Journal
Accession number :
edsdoj.450706c3ecf540078e5ada4fd1496110
Document Type :
article
Full Text :
https://doi.org/10.3389/ijph.2022.1604427