Therapeutic advances of miRNAs: A preclinical and clinical update

Background: miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times. Aim of the Review: A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed. Key Scientific Concepts of Review: In this work, biopharmaceutical companies working with miRNAs and the current status of preclinical/clinical trials about miRNA therapeutics have been reviewed. Finally, recent updates on the absorption, distribution, metabolism, and excretion (ADME), as well as a delivery system of miRNAs, have been illustrated.