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Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- TET2 catalyses DNA demethylation and is mutated in various blood cancers; in particularTet2null mice develop haematological neoplasms. Here the authors show that this effect could be due to the increased frequency of mutation associated with TET2 loss in haematopoietic stem/progenitor cells.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 44059930
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.44968fa5d84b440599307b3e8bfee622
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms15102