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Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism

Authors :
Zheng Fu
Joseph W. Dean
Lifeng Xiong
Michael W. Dougherty
Kristen N. Oliff
Zong-ming E. Chen
Christian Jobin
Timothy J. Garrett
Liang Zhou
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

RORγt is known to play critical roles in the regulation of a number of immune cell subsets. Here the authors implicate mitochondrial transcription factor A in the regulation of intestinal RORγt + lymphocyte homeostasis and metabolic control in a murine in vivo model.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.446f53463c9844739ef9f5446fb56343
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-24755-9