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Cross-tissue analysis of blood and brain epigenome-wide association studies in Alzheimer’s disease

Authors :
Tiago C. Silva
Juan I. Young
Lanyu Zhang
Lissette Gomez
Michael A. Schmidt
Achintya Varma
X. Steven Chen
Eden R. Martin
Lily Wang
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

DNA methylation differences in Alzheimer’s disease have been previously reported, although the interpretation of the differences is unclear. Here, the authors performed epigenome-wide meta-analyses of DNA methylation in blood and brain, and developed a methylation-based risk prediction model for AD.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.43df6e2bbc7a4b2eb04e9c03de3ff40c
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-32475-x