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Use of probiotics in patients with chronic kidney disease on hemodialysis: a randomized clinical trial

Authors :
Érica Maria Rodrigues de Araújo
Gdayllon Cavalcante Meneses
Antônio Augusto Ferreira Carioca
Alice Maria Costa Martins
Elizabeth De Francesco Daher
Geraldo Bezerra da Silva Junior
Source :
Brazilian Journal of Nephrology (2022)
Publication Year :
2022
Publisher :
Sociedade Brasileira de Nefrologia, 2022.

Abstract

ABSTRACT Introduction: Supplementation with probiotics for patients with chronic kidney disease (CKD) may be associated with decreased systemic inflammation. Objective: To assess the impact of oral supplementation with probiotics for patients with CKD on hemodialysis. Method: This double-blind randomized clinical trial included 70 patients on hemodialysis; 32 were given oral supplementation with probiotics and 38 were in the placebo group. Blood samples were collected at the start of the study and patients were given oral supplementation with probiotics or placebo for three months. The probiotic supplement comprised four strains of encapsulated Gram-positive bacteria: Lactobacillus Plantarum A87, Lactobacillus rhamnosus, Bifidobacterium bifidum A218 and Bifidobacterium longum A101. Patients were given one capsule per day for 3 months. Blood samples were taken throughout the study to check for inflammatory biomarkers. Non-traditional biomarkers Syndecan-1, IFN-y, NGAL, and cystatin C were measured using an ELISA kit, along with biochemical parameters CRP, calcium, phosphorus, potassium, PTH, GPT, hematocrit, hemoglobin, glucose, and urea. Results: Patients given supplementation with probiotics had significant decreases in serum levels of syndecan-1 (239 ± 113 to 184 ± 106 ng/mL, p = 0.005); blood glucose levels also decreased significantly (162 ± 112 to 146 ± 74 mg/dL, p = 0.02). Conclusion: Administration of probiotics to patients with advanced CKD was associated with decreases in syndecan-1 and blood glucose levels, indicating potential improvements in metabolism and decreased systemic inflammation.

Details

Language :
English, Portuguese
ISSN :
21758239
Database :
Directory of Open Access Journals
Journal :
Brazilian Journal of Nephrology
Publication Type :
Academic Journal
Accession number :
edsdoj.43d47d462a6c4e7895d0c42ed95f26af
Document Type :
article
Full Text :
https://doi.org/10.1590/2175-8239-jbn-2022-0021en