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Association between serum vitamin D level and insulin resistance in overweight adolescents
- Source :
- O Mundo da Saúde, Vol 47 (2023)
- Publication Year :
- 2023
- Publisher :
- Centro Universitário São Camilo, 2023.
-
Abstract
- The maintenance of glycemic homeostasis and insulin secretion is considered one of the metabolic effects of vitamin D (VD). Traditionally, obesity is the main cause of insulin resistance (IR) and an important risk factor for VD deficiency. Therefore, adolescents with obesity and VD deficiency may be faced with a doubled risk of developing IR. The objective of this study was to evaluate the association between serum levels of 25-hydroxyvitamin D [25(OH)D] and IR parameters in overweight adolescents. This is an observational study of 42 overweight adolescents followed in a secondary care service. Overweight was defined by the criteria of the World Health Organization and serum levels of 25(OH)D were categorized as normal (≥ 30 ng/mL) and low (< 30 ng/mL) according to the Brazilian Society of Nutrology. In the assessment of IR, the homeostatic model of IR assessment (HOMA-IR), the glucose/insulin ratio and fasting insulinemia were used. The studied group was characterized as being predominantly young adolescents (88.1% between 10 and 14 years old), in puberty (83.5%), and having central obesity (80%), and hypovitaminosis D (85.7%). Adolescents with low VD showed a higher occurrence of IR according to the HOMAR IR index (one-tailed Fisher test, p
- Subjects :
- vitamin d
adolescent
obesity
insulin resistance
Medicine (General)
R5-920
Subjects
Details
- Language :
- English, Portuguese
- ISSN :
- 01047809 and 19803990
- Volume :
- 47
- Database :
- Directory of Open Access Journals
- Journal :
- O Mundo da Saúde
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.437a7b6e3a34476486d2692587842b2c
- Document Type :
- article
- Full Text :
- https://doi.org/10.15343/0104-7809.202347e11842021P