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Biomass‐derived washable composites for accelerating the healing of infected wounds
- Source :
- BMEMat, Vol 1, Iss 4, Pp n/a-n/a (2023)
- Publication Year :
- 2023
- Publisher :
- Wiley, 2023.
-
Abstract
- Abstract Advanced sustainable biomedical materials are urgently needed for clinical applications; however, developing biomedical materials with exceptional mechanical and bactericidal properties as well as removable functionalities to reduce unintended secondary injury remains a challenge. Here, we report a biomass‐derived composite consisting of water‐soluble fish gelatin (FG) and antibacterial ZnO@silk fibroin (ZSF) microspheres for potential application as the wound dressing. The ZSF microspheres are embedded in a FG matrix to realize the stretchable, antibacterial, and removable ZSF/FG composites. By introducing glycerin as the plasticizer, ZSF/FG composites deliver a tensile strength of 4.5 MPa and stretchability of 550%. Acting as both the germicide and hydrophile components, ZSF microspheres endow the composites with excellent antibacterial capacity and water solubility. To prevent secondary injury, the ZSF/FG composites can be easily removed from the wounds by simply exposing them to excess water. Additionally, the ZSF/FG composites exhibit favorable biocompatibility and sustain high cell viability of over 100%. The full‐thickness skin wound model on infected mice demonstrated an efficient rate of wound closure and a reduced inflammatory response. The ZSF/FG composite shows promise to hasten the healing of infected wounds and is expected a promising candidate as wound dressing for clinical therapy.
Details
- Language :
- English
- ISSN :
- 27517446
- Volume :
- 1
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- BMEMat
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4340e03f681f421fb522f73a3c816878
- Document Type :
- article
- Full Text :
- https://doi.org/10.1002/bmm2.12055