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The therapeutic potential of neural stem/progenitor cells in murine globoid cell leukodystrophy is conditioned by macrophage/microglia activation
- Source :
- Neurobiology of Disease, Vol 21, Iss 2, Pp 314-323 (2006)
- Publication Year :
- 2006
- Publisher :
- Elsevier, 2006.
-
Abstract
- Twitcher (GALCtwi/twi) is the murine model of globoid cell leukodystrophy (GLD or Krabbe disease), a disease caused by mutations of the lysosomal enzyme galactocerebrosidase (GALC). To verify the therapeutic potential on twitcher of neural stem/progenitor cells (NSPC), we transduced them with a GALC lentiviral vector. Brain injection of NSPC-GALC increased survival of GALCtwi/twi from 36.1 ± 4.1 to 52.2 ± 5.6 days (P
Details
- Language :
- English
- ISSN :
- 1095953X
- Volume :
- 21
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Neurobiology of Disease
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4325cc85d9894a2396c95274ade04de8
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.nbd.2005.07.016