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MTHFR, XRCC1 and OGG1 genetic polymorphisms in breast cancer: a case-control study in a population from North Sardinia

Authors :
Matteo Floris
Daria Sanna
Paolo Castiglia
Carlo Putzu
Valeria Sanna
Antonio Pazzola
Maria Rosaria De Miglio
Francesca Sanges
Giovanna Pira
Antonio Azara
Emanuele Lampis
Antonello Serra
Ciriaco Carru
Maristella Steri
Flavia Costanza
Marco Bisail
Maria Rosaria Muroni
Source :
BMC Cancer, Vol 20, Iss 1, Pp 1-15 (2020)
Publication Year :
2020
Publisher :
BMC, 2020.

Abstract

Abstract Background Despite conflicting results, considerable evidence suggests the association between single nucleotide polymorphisms in MTHFR, XRCC1 and OGG1 genes and, risk of developing breast cancer. Here a case-control study is reported, including 135 breat cancer patients and 112 healthy women, all representative of Northern Sardinian population. Methods Polymerase chain reaction/restriction fragment length polymorphism method was used to determine the genotypes of five polymorphisms: MTHFR C677T (rs1801133) and A1298C (rs1801131), XRCC1 Arg194Trp (rs1799782) and Arg399Gln (rs25487) and OGG1 Ser326Cys (rs1052133). Allelic, genotypic and haplotype association analyses with disease risk and clinicopathological parameters were performed. Results A nominally significant association with breast cancer risk was observed for MTHFR C677T polymorphism heterozygous genotype in the codominant model (OR: 0.57, 95% CI: 0.32–1.00, p = 0.049) and for Cys/Cys genotype of the OGG1 Ser326Cys polymorphism in the recessive model (OR: 0.23, 95% CI: 0.05–1.11, p = 0.0465). No significant differences were found at genotype-level for A1298C polymorphism of the MTHFR gene and Arg194Trp and Arg399Gln of the XRCC1 gene. Furthermore, the OGG1 and XRCC1 rs25487 polymorphisms were nominally associated with PgR, Her2 status and with sporadic breast cancer, respectively. Conclusions Based on genetic characteristics of individuals included in this study, results suggest that MTHFR CT and OGG1 Cys/Cys genotypes have a protective effect that may have an influence on breast cancer risk in a representative Northern Sardinian population.

Details

Language :
English
ISSN :
14712407
Volume :
20
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Cancer
Publication Type :
Academic Journal
Accession number :
edsdoj.431e9ff0f79f4e30811cd02534df8578
Document Type :
article
Full Text :
https://doi.org/10.1186/s12885-020-06749-w