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Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage

Authors :
Simon G. Pfisterer
Gergana Gateva
Peter Horvath
Juho Pirhonen
Veijo T. Salo
Leena Karhinen
Markku Varjosalo
Samppa J. Ryhänen
Pekka Lappalainen
Elina Ikonen
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Lipid droplets (LDs) are cellular organelles dedicated to triacylglycerol storage that can undergo fusion and dissociation events. Here the authors show that formin-like 1-dependent acto-myosin assembly on LDs facilitates their dissociation and, as a consequence, affects hydrolysis and storage of triacylglycerols.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.431a9166504d47adae4b3f6abb8d16
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms14858