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Down-regulation of hepatic G-6-Pase expression in hyperglycemic rats: Intervention with biogenic gold nanoconjugate
- Source :
- Saudi Journal of Biological Sciences, Vol 27, Iss 12, Pp 3334-3341 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Chronic diabetes extensively complicates the glucose metabolism to onset and progress the complication. Concurrently, several contemporary medicines, especially organo-metallic formulations, are emerging to treat hyperglycemia. The current study aims to emphasize the gold nanoparticles (GNPs) potential for glucose metabolism regulation in Streptozotocin (STZ) induced diabetes. Quantitative real-time polymerase chain reaction (RT-PCR) was carried out to detect the mRNA expression of Glucose transporters 2 (GLUT2), Glucokinase (GK) and Glucose 6 Phosphatase (G-6-Pase). The study shows remarkable results such as the prognostic effect of GNPs in reinforcing the repression of enzyme complex G-6-Pase about 13.3-fold when compared to diabetes control. Also, molecular docking studies showed significant inhibition of G-6-Pase by the terpenoid ligands with alpha and beta amyrin from leaf extract of Couroupita guianensis. Thus the study explored the novel mechanism of G-6-Pase downregulated by GNPs intervention that majorly contributes to the regulation of circulatory glucose homeostasis during diabetes.
Details
- Language :
- English
- ISSN :
- 1319562X
- Volume :
- 27
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Saudi Journal of Biological Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.4303308de0214a74aafd991734619ea5
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.sjbs.2020.09.026