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Nongenomic Mechanisms of PTEN Regulation

Authors :
Jimmie E. Fata
Shawon Debnath
Edmund C. Jenkins
Marcia V. Fournier
Source :
International Journal of Cell Biology, Vol 2012 (2012)
Publication Year :
2012
Publisher :
Hindawi Limited, 2012.

Abstract

A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes. As the cellular mechanisms that regulate normal PTEN enzymatic activity resolve, it is evident that deregulation of these mechanisms can alter cellular processes and tissue architecture and ultimately lead to oncogenic transformation. Here we discuss PTEN ubiquitination, PTEN complex formation with components of the adherens junction, PTEN nuclear localization, and microRNA regulation of PTEN as essential regulatory mechanisms that determine PTEN function independent of gene mutations and epigenetic events.

Subjects

Subjects :
Cytology
QH573-671

Details

Language :
English
ISSN :
16878876 and 16878884
Volume :
2012
Database :
Directory of Open Access Journals
Journal :
International Journal of Cell Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.427e906aec29432fb8d7e199f883d9f1
Document Type :
article
Full Text :
https://doi.org/10.1155/2012/379685