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Abdominal angiostrongyliasis can be diagnosed with a immunochromatographic rapid test with recombinant galactin from Angiostrongylus cantonensis

Authors :
Carlos Graeff-Teixeira
Vanessa Fey Pascoal
Rubens Rodriguez
Alessandra Loureiro Morassutti
Pewpan M Intapan
Wanchai Maleewong
Source :
Memorias do Instituto Oswaldo Cruz, Vol 115 (2020)
Publication Year :
2020
Publisher :
Fundação Oswaldo Cruz (FIOCRUZ), 2020.

Abstract

Angiostrongylus costaricensis is the causative agent of abdominal angiostrongyliasis, a zoonotic infection that may produce severe eosinophilic enterocolitis or hepatitis in humans. Parasites are usually not released in stools and serology has an important role in diagnosis. Since cross-reactivity is demonstrated between A. costaricensis and another metastrongylid worm, A. cantonensis, we tested heterologous recombinant galectin as a probe in an immunochromatographic rapid diagnostic test (ICT-RDT) for detection of anti-A. costaricensis antibodies. Almost all (11/12) positive control sera from A. costaricensis infected patients were positive at ICT RDT. These are preliminary indications that r-galectin ICT-RDT is useful for diagnosing A. costaricensis infection.

Details

Language :
English
ISSN :
16788060 and 00740276
Volume :
115
Database :
Directory of Open Access Journals
Journal :
Memorias do Instituto Oswaldo Cruz
Publication Type :
Academic Journal
Accession number :
edsdoj.427d5fa5024211a1939cb53bf85f96
Document Type :
article
Full Text :
https://doi.org/10.1590/0074-02760200201