Effect of dietary supplements on Se bioavailability: A comprehensive in vitro and in vivo study

Selenium (Se) is an essential micronutrient for animals and humans, and it is present in many different forms with different levels of bioaccessibility in food. Based on the maldistribution of Se and overall low level of Se dietary intake in China, an integrated study was conducted in this thesis to provide references for the regulation of Se nutrition. An in vitro simulation test was used to monitor the concentration effects, the impacts of dietary supplement combinations on the bioaccessibility of Se were examined in rice, and a model animal experiment (in vivo) was used to evaluate the practicability of the Se nutrition regulation scheme. The main results were as follows: the bioaccessibility of Se was effectively increased by 30 mg·d−1 VE (VE), 300 mg·d−1 VC + 300 μg·d−1 VB9 (VC+VB9) and 30 mg·d−1 VE + 300 mg·d−1 VC + 300 μg·d−1 VB9 (3IN1) (P