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Altered Levels of Natural Autoantibodies against Heat Shock Proteins in Pregnant Women with Hashimoto’s Thyroiditis

Authors :
Diána Simon
Szabina Erdő-Bonyár
Katalin Böröcz
Noémi Balázs
Ahmed Badawy
Anna Bajnok
Jasper Nörenberg
Tímea Serény-Litvai
Ákos Várnagy
Kálmán Kovács
Eszter Hantosi
Emese Mezősi
Péter Németh
Tímea Berki
Source :
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1423 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

The function of natural autoantibodies (nAAbs) in maintaining immunological tolerance has been comprehensively explained; however, their function in pregnant patients dealing with autoimmune diseases has not been thoroughly investigated. As Hashimoto’s thyroiditis (HT) is the predominant organ-specific autoimmune condition of women of childbearing age, this study’s objective was to evaluate IgM and IgG nAAbs targeting mitochondrial citrate synthase (CS) and heat shock proteins (Hsp60 and Hsp70) in women diagnosed with HT who were pregnant (HTP). Serum samples collected from HTP and healthy pregnant (HP) women in the first and third trimesters were tested using in-house-developed enzyme-linked immunosorbent assays (ELISAs). Our findings indicate the stability of nAAbs against CS and Hsps throughout the pregnancies of both healthy women and those with HT. However, during both trimesters, HTP patients displayed elevated levels of IgM isotype nAAbs against Hsp60 and Hsp70 compared to HP women, suggesting a regulatory role of IgM nAAbs during the pregnancies of patients with HT. Nonetheless, levels of IgG isotype nAAbs against Hsps were lower solely in the third trimester among HTP patients, resulting in a higher IgM/IgG ratio, which indicates their importance in alterations of the nAAb network during pregnancy in patients with HT.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
25
Issue :
3
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.424a3e70ce564116be14b5aaa544fdf2
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms25031423