Association between body roundness index and risk of ultrasound-defined non-alcoholic fatty liver disease

Objectives: While several indicators have been studied, the association of body roundness index (BRI) with non-alcoholic fatty liver disease (NAFLD) remains unclear. We aimed to explore the association between BRI and ultrasound-defined NAFLD. Methods: The sample dataset was extracted from the National Health and Nutrition Examination Survey (NHANES) during the period of 2017–2018. The diagnosis of NAFLD was determined based on the controlled attenuated parameter (CAP≥248 dB/m) score of liver ultrasound transient elastography (LUTE). Participants with excessive alcohol use and viral hepatitis were excluded. To delve deeper into the relationship, Multivariable logistic regression with adjustment for confounding variables and smoothing curve analysis was used to investigate the association and nonlinear relationships between BRI and NAFLD. Results: Among 4210 individuals aged 20 years or older included in the study, 28.2 % had NAFLD. Compared to the first tertile, BRI notably increased the risk of NAFLD 3.53-fold [95 % confidence interval (CI) = 2.73–4.57] in the second tertile and 7.00-fold (95%CI = 5.29–9.27) in the third tertile after adjusting for multiple covariates (P for trend