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Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites

Authors :
Chiung-Yao Huang
Che-Wei Chang
Yen-Ju Tseng
Jessica Lee
Ping-Jyun Sung
Jui-Hsin Su
Tsong-Long Hwang
Chang-Feng Dai
Hui-Chun Wang
Jyh-Horng Sheu
Source :
Marine Drugs, Vol 14, Iss 10, p 180 (2016)
Publication Year :
2016
Publisher :
MDPI AG, 2016.

Abstract

Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4–11), were isolated from a Formosan marine soft coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound 3 is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds 1–3 and 5 displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 2 and 5 exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds 1–11 were also examined to evaluate the anti-inflammatory potential, and 2–4 were shown to exhibit significant activities.

Details

Language :
English
ISSN :
16603397
Volume :
14
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Marine Drugs
Publication Type :
Academic Journal
Accession number :
edsdoj.421c33a011bd4b66a4223fa55c01f9f1
Document Type :
article
Full Text :
https://doi.org/10.3390/md14100180