Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.

Authors :: Rico Rueedi
Mirko Ledda
Andrew W Nicholls
Reza M Salek
Pedro Marques-Vidal
Edgard Morya
Koichi Sameshima
Ivan Montoliu
Laeticia Da Silva
Sebastiano Collino
François-Pierre Martin
Serge Rezzi
Christoph Steinbeck
Dawn M Waterworth
Gérard Waeber
Peter Vollenweider
Jacques S Beckmann
Johannes Le Coutre
Vincent Mooser
Sven Bergmann
Ulrich K Genick
Zoltán Kutalik
Source :: PLoS Genetics, Vol 10, Iss 2, p e1004132 (2014)
Publication Year :: 2014
Publisher :: Public Library of Science (PLoS), 2014.
Abstract: Metabolic traits are molecular phenotypes that can drive clinical phenotypes and may predict disease progression. Here, we report results from a metabolome- and genome-wide association study on (1)H-NMR urine metabolic profiles. The study was conducted within an untargeted approach, employing a novel method for compound identification. From our discovery cohort of 835 Caucasian individuals who participated in the CoLaus study, we identified 139 suggestively significant (P

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