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LINC01234 promoted malignant behaviors of breast cancer cells via hsa-miR-30c-2-3p/CCT4/mTOR signaling pathway

Authors :
Chuangang Tang
Changwen Li
Chengling Chen
Tao Chen
Juan Zhu
Mingyu Sun
Pei Wang
Conghui Han
Source :
Taiwanese Journal of Obstetrics & Gynecology, Vol 63, Iss 1, Pp 46-56 (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Objective: Despite continuous progress in treatment, recurrence and metastasis limit further improvement in the prognosis of breast cancer (BC) patients. Our aim was to search for a crucial prognostic biomarker of BC. Materials and methods: Patient data were selected from The Cancer Genome Atlas (TCGA) and GTEx databases. Several online public databases, including Gene Expression Profiling Interactive Analysis (GEPIA), miRWalk, miRDB, and LncBase Predicted v.2, were used to identify potential upstream miRNAs and lncRNAs. These findings were validated through in vitro experiments. Results: A total of 1, 097 invasive BC samples and 572 normal breast tissues (including 113 samples from TCGA and 459 samples from GTEx) were collected for the study. CCT4 was not only significantly overexpressed in BC compared with normal breast tissues but also had important prognostic significance (P

Details

Language :
English
ISSN :
10284559
Volume :
63
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Taiwanese Journal of Obstetrics & Gynecology
Publication Type :
Academic Journal
Accession number :
edsdoj.414e7d7715164ea99e9432b492699a02
Document Type :
article
Full Text :
https://doi.org/10.1016/j.tjog.2023.09.019