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APPROACHES TO THE LIPID METABOLISM GENES POLYMORPHYSM ANALYSIS IN SCREENING FOR ATHEROSCLEROSIS RISK FACTORS

Authors :
N. V. Koch
G. I. Lifschitz
E. N. Voronina
Source :
Российский кардиологический журнал, Vol 0, Iss 10, Pp 53-057 (2014)
Publication Year :
2014
Publisher :
«FIRMA «SILICEA» LLC, 2014.

Abstract

The review concerns he etiology of polygenic hyperlipidemias. The most prominent and prevalent in more than 1% of inhabitants genetic markers are discussed. The mechanisms of minor alleles influence on the hypercholesterolemia are shown: APOAI 75G>A (rs670), CETP (rs5882), LIPC (rs1800588), APOE (E2/E3/E4), hypertrigliceridemia: APOA5 (rs3135506), FABP2 rs1799883, LPL rs328. Also the genetic markers discussed that influence food-seeking behavior and by various ways do increase daily fat intake: CD36 (rs1761667), FTO (rs8050136), MC4R (rs17782313). Carrying of several pathologic alleles in a patients does significantly increase the risk of primary hyperlipidemias. More studies needed to evaluate the effect of different genetic markers combination to invent these tests as an instrument of personified predictive medicine in clinical practice.

Details

Language :
Russian
ISSN :
15604071 and 26187620
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Российский кардиологический журнал
Publication Type :
Academic Journal
Accession number :
edsdoj.40ecd10eca545f0bbd972eda0932ddd
Document Type :
article
Full Text :
https://doi.org/10.15829/1560-4071-2014-10-53-057