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Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- The molecular mechanisms underlying cervical carcinogenesis following integration of HPV DNA into the human genome remain elusive. Here, the authors perform long-read sequencing in 16 HPV16-positive cervical tumors and identify distinct integration types, structural variations and potential driver genes.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.40d0acc9bc143a3b670401e65c9c657
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-30190-1