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Core-Shell Fe3O4@C Nanoparticles as Highly Effective T2 Magnetic Resonance Imaging Contrast Agents: In Vitro and In Vivo Studies

Authors :
Huan Yue
Dejun Zhao
Tirusew Tegafaw
Mohammad Yaseen Ahmad
Abdullah Khamis Ali Al Saidi
Ying Liu
Hyunsil Cha
Byeong Woo Yang
Kwon Seok Chae
Sung-Wook Nam
Yongmin Chang
Gang Ho Lee
Source :
Nanomaterials, Vol 14, Iss 2, p 177 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Magnetite nanoparticles (Fe3O4 NPs) have been intensively investigated because of their potential biomedical applications due to their high saturation magnetization. In this study, core–shell Fe3O4@C NPs (core = Fe3O4 NPs and shell = amorphous carbons, davg = 35.1 nm) were synthesized in an aqueous solution. Carbon coating terminated with hydrophilic –OH and –COOH groups imparted excellent biocompatibility and hydrophilicity to the NPs, making them suitable for biomedical applications. The Fe3O4@C NPs exhibited ideal relaxometric properties for T2 magnetic resonance imaging (MRI) contrast agents (i.e., high transverse and negligible longitudinal water proton spin relaxivities), making them exclusively induce only T2 relaxation. Their T2 MRI performance as contrast agents was confirmed in vivo by measuring T2 MR images in mice before and after intravenous injection.

Details

Language :
English
ISSN :
20794991
Volume :
14
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Nanomaterials
Publication Type :
Academic Journal
Accession number :
edsdoj.4087a15e10450f92a9f425ec95006d
Document Type :
article
Full Text :
https://doi.org/10.3390/nano14020177