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Curcuminoids as Anticancer Drugs: Pleiotropic Effects, Potential for Metabolic Reprogramming and Prospects for the Future

Authors :
Daniel L. Pouliquen
Koraljka Gall Trošelj
Ruby John Anto
Source :
Pharmaceutics, Vol 15, Iss 6, p 1612 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

The number of published studies on curcuminoids in cancer research, including its lead molecule curcumin and synthetic analogs, has been increasing substantially during the past two decades. Insights on the diversity of inhibitory effects they have produced on a multitude of pathways involved in carcinogenesis and tumor progression have been provided. As this wealth of data was obtained in settings of various experimental and clinical data, this review first aimed at presenting a chronology of discoveries and an update on their complex in vivo effects. Secondly, there are many interesting questions linked to their pleiotropic effects. One of them, a growing research topic, relates to their ability to modulate metabolic reprogramming. This review will also cover the use of curcuminoids as chemosensitizing molecules that can be combined with several anticancer drugs to reverse the phenomenon of multidrug resistance. Finally, current investigations in these three complementary research fields raise several important questions that will be put among the prospects for the future research related to the importance of these molecules in cancer research.

Details

Language :
English
ISSN :
15061612 and 19994923
Volume :
15
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.407bb2e9fed9487898ae496be5d9fd61
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics15061612