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The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism
- Source :
- Saudi Pharmaceutical Journal, Vol 25, Iss 4, Pp 666-670 (2017)
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- For patients who have sepsis, acute lung injury (ALI) causes most of death. Metformin (Met) is an anti-hyperglycemic agent and it has extensive pharmacological properties. This study aimed to analyze the influence of Met on lipopolysaccharide (LPS) -induced ALI. Met (1, 2, and 4 mg/kg) were injected and LPS was injected 30 min later. The data suggested Met can reduce release of inflammatory cytokines and bronchoalveolar lavage fluid (BALF) protein expression, reduce lung wet/dry ratio, and significantly improve LPS-induced lung destruction during ALI. In addition, Met inhibits LPS-induced neutrophil and macrophage infiltration, reduces MPO activity, and promotes AMPK-α1 expression in lung tissues. Our data suggested that metformin alleviates capillary injury during ALI via AMPK-α1. Keywords: Metformin, Sepsis, Acute respiratory distress syndrome
- Subjects :
- Therapeutics. Pharmacology
RM1-950
Subjects
Details
- Language :
- English
- ISSN :
- 13190164
- Volume :
- 25
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Saudi Pharmaceutical Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.40497bbb895485b84b2c48155281f82
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jsps.2017.05.001