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Analysis of Neutralization Antibodies in Patients With Mild COVID-19 Infection After 100 Days Using Microneutralization Test
- Source :
- Annals of Clinical Microbiology, Vol 25, Iss 1, Pp 29-33 (2022)
- Publication Year :
- 2022
- Publisher :
- Korean Society of Clinical Microbiology, 2022.
-
Abstract
- Neutralizing antibodies play a critical role in blocking viral infections and in viral clearance during acute infection. The microneutralization assay and enzyme-linked immunosorbent assay (ELISA) targeting the receptor binding domain were performed for 30 patients with mild coronavirus disease (COVID)-19 infections. The elapsed number of days between sample collection and diagnosis was 115 days, and real-time polymerase chain reaction (PCR) cycle threshold (Ct) values at diagnosis were recorded. Clinical characteristics and Ct values were compared between neutralization antibody-positive and -negative patients as measured by the microneutralization assay. Neutralization antibody-positive patients (n = 9) were likely to be older, have low Ct values, have more pneumonia during admission, and have a higher optical density in ELISA than the neutralization antibody-negative patients (n = 21). Elderly people seemed to have a higher viral load causing more pneumonia and to produce more neutralization antibodies. Neutralization antibodies persisted in only 30% of patients as detected by microneutralization test after 100 days of diagnosis.
- Subjects :
- antibody
covid-19
neutralization
sars-cov-2
Microbiology
QR1-502
Subjects
Details
- Language :
- English, Korean
- ISSN :
- 22880585 and 22886850
- Volume :
- 25
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Annals of Clinical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.404248f2397c4c81b1b11a7d0df3177a
- Document Type :
- article
- Full Text :
- https://doi.org/10.5145/ACM.2022.25.1.4