Back to Search
Start Over
Global analysis of A-to-I RNA editing reveals association with common disease variants
- Source :
- PeerJ, Vol 6, p e4466 (2018)
- Publication Year :
- 2018
- Publisher :
- PeerJ Inc., 2018.
-
Abstract
- RNA editing modifies transcripts and may alter their regulation or function. In humans, the most common modification is adenosine to inosine (A-to-I). We examined the global characteristics of RNA editing in 4,301 human tissue samples. More than 1.6 million A-to-I edits were identified in 62% of all protein-coding transcripts. mRNA recoding was extremely rare; only 11 novel recoding sites were uncovered. Thirty single nucleotide polymorphisms from genome-wide association studies were associated with RNA editing; one that influences type 2 diabetes (rs2028299) was associated with editing in ARPIN. Twenty-five genes, including LRP11 and PLIN5, had editing sites that were associated with plasma lipid levels. Our findings provide new insights into the genetic regulation of RNA editing and establish a rich catalogue for further exploration of this process.
Details
- Language :
- English
- ISSN :
- 21678359
- Volume :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- PeerJ
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.400c7a24f8b34d1b987fdf4d12315de7
- Document Type :
- article
- Full Text :
- https://doi.org/10.7717/peerj.4466