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Generating Vectors for the Lattice Structures of Tubular and Conical Viral Capsids

Authors :
Sadre-Marandi Farrah
Liu Jiangguo
Tavener Simon
Chen Chaoping
Source :
Computational and Mathematical Biophysics, Vol 2, Iss 1, Pp 128-140 (2014)
Publication Year :
2014
Publisher :
De Gruyter, 2014.

Abstract

Retrovirus capsid is a fullerene-like lattice consisting of capsid protein hexamers and pentamers. Mathematical models for the lattice structure help understand the underlying biological mechanisms in the formation of viral capsids. It is known that viral capsids could be categorized into three major types: icosahedron, tube, and cone. While the model for icosahedral capsids is established and well-received, models for tubular and conical capsids need further investigation. This paper proposes new models for the tubular and conical capsids based on an extension of the Capser-Klug quasi-equivalence theory. In particular, two and three generating vectors are used to characterize respectively the lattice structures of tubular and conical capsids. Comparison with published HIV-1 data demonstrates a good agreement of our modeling results with experimental data.

Details

Language :
English
ISSN :
25447297
Volume :
2
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Computational and Mathematical Biophysics
Publication Type :
Academic Journal
Accession number :
edsdoj.40055a487c244de7aa31f159d3e5095c
Document Type :
article
Full Text :
https://doi.org/10.2478/mlbmb-2014-0009