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Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Tobacco use is one of the major risk factors for Head and neck squamous cell carcinoma (HNSCC). Here, the authors report an immune-competent syngeneic mouse model that mimics human tobacco-related HNSCC, and develops tumors in the tongue, and report a high response rate to anti-CTLA-4 therapy.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3fd2a00b6d274d9893b38fa9d6f2e131
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-13471-0