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HPV and RAD51 as Prognostic Factors for Survival in Inoperable Oral and Oropharyngeal Cancer in Patients Unfit for Chemotherapy Treated with Hyperfractionated Radiotherapy

Authors :
Zuzana Zděblová Čermáková
Pavel Hurník
David Konvalinka
Jan Štembírek
Tereza Paračková
Kamila Resová
Jakub Cvek
Tomáš Blažek
Lukáš Knybel
Martin Formánek
Mariam Gachechiladze
Markus Joerger
Alex Soltermann
Jozef Škarda
Oldřich Motyka
Jana Janoutová
Source :
Medicina, Vol 59, Iss 2, p 361 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Introduction: The incidence of advanced oral cavity and oropharyngeal cancers is generally high. Treatment outcomes for patients, especially those unfit for comprehensive cancer treatment, are unsatisfactory. Therefore, the search for factors to predict response to treatment and increase overall survival is underway. Objective: This study aimed to analyze the presence of 32 HPV genotypes in tumor samples of 34 patients and the effect of HPV status and RAD51 on overall survival. Method: Tumor samples of 34 patients with locally advanced oropharyngeal or oral cavity cancer treated with accelerated radiotherapy in monotherapy were analyzed using reverse hybridization and immunohistochemistry for the presence of HPV and RAD51. Its effect on overall survival was examined. Results: Only two types of HPV were identified—HPV 16 (dominant) and HPV 66 (two samples). The HPV positivity was associated with a borderline insignificant improvement in 2-year (p = 0.083), 5-year (p = 0.159), and overall survival (p = 0.083). Similarly, the RAD51 overexpression was associated with borderline insignificant improvement in 2-year (p = 0.083) and 5-year (p = 0.159) survival. Conclusion: We found no statistically significant differences but detected trends toward improvement in the survival of HPV-positive and RAD51 overexpressing patients unfit for surgical treatment or chemotherapy treated with hyperfractionated radiotherapy. The trends, however, indicate that in a larger group of patients, the effects of these two parameters would likely be statistically significant.

Details

Language :
English
ISSN :
16489144 and 1010660X
Volume :
59
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Medicina
Publication Type :
Academic Journal
Accession number :
edsdoj.3fbdc18cc242049c3c14b69da5670d
Document Type :
article
Full Text :
https://doi.org/10.3390/medicina59020361