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Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids
Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids
- Source :
- Molecules, Vol 14, Iss 12, Pp 5042-5053 (2009)
- Publication Year :
- 2009
- Publisher :
- MDPI AG, 2009.
-
Abstract
- A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC50 values of 11.6 and 6.1 mM, respectively.
- Subjects :
- PBTs
synthesis
cytotoxicity
Organic chemistry
QD241-441
Subjects
Details
- Language :
- English
- ISSN :
- 14203049 and 75328143
- Volume :
- 14
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3fb5ad75328143caa6f34d1ac347856e
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/molecules14125042