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Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids

Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids

Authors :
Zhanyou Wang
Xueshi Huang
Yingbo Fu
Jiang Liu
Dan Zheng
Liang Sun
Songtao Li
Li Han
Source :
Molecules, Vol 14, Iss 12, Pp 5042-5053 (2009)
Publication Year :
2009
Publisher :
MDPI AG, 2009.

Abstract

A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC50 values of 11.6 and 6.1 mM, respectively.

Details

Language :
English
ISSN :
14203049 and 75328143
Volume :
14
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.3fb5ad75328143caa6f34d1ac347856e
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules14125042