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5-Fluorouracil/L-Leucovorin Plus Oxaliplatin (FOLFOX) Regimen as Salvage Chemotherapy for Patients with Unresectable Pancreatic Cancer Receiving Gemcitabine and Nab-Paclitaxel and 5-Fluorouracil/L-Leucovorin Plus Nanoliposomal Irinotecan: Preliminary Results from Clinical Practice

Authors :
Takuo Yamai
Kenji Ikezawa
Yasuharu Kawamoto
Takeru Hirao
Sena Higashi
Kazuma Daiku
Shingo Maeda
Yutaro Abe
Makiko Urabe
Yugo Kai
Ryoji Takada
Tasuku Nakabori
Hiroyuki Uehara
Kazuyoshi Ohkawa
Source :
Current Oncology, Vol 29, Iss 4, Pp 2644-2649 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Salvage chemotherapy for patients with unresectable pancreatic cancer (UR-PC) who have been treated with gemcitabine and nab-paclitaxel (GnP), and 5-fluorouracil (5-FU)/l-leucovorin (LV) plus nanoliposomal irinotecan (nal-IRI), has not been fully established. We retrospectively reviewed data from 17 patients with UR-PC who initiated 5-FU/l-LV plus oxaliplatin (FOLFOX) as salvage chemotherapy at our hospital between June 2020 and August 2021, after treatment with GnP and 5-FU/LV plus nal-IRI. The primary endpoint was tumor response. The secondary endpoints were progression-free survival (PFS) and adverse events (AEs). The response and disease control rates were 5.9% (1/17) and 17.6% (3/17), respectively. The median PFS was 1.8 months (range: 0.4–5.2 months). Eight patients (47.1%) experienced grade 3 nonhematologic AEs, while none experienced grade 3 hematologic AEs. Two patients with controlled disease had homologous recombination deficiency (HRD)-associated gene mutations in cancer panel testing. The FOLFOX regimen benefit for UR-PC patients treated with GnP and 5-FU/LV plus nal-IRI may be limited to patients with HRD-associated gene mutations.

Details

Language :
English
ISSN :
17187729 and 11980052
Volume :
29
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Current Oncology
Publication Type :
Academic Journal
Accession number :
edsdoj.3f9eb9aea2f4fc5a91b1dacf21a240c
Document Type :
article
Full Text :
https://doi.org/10.3390/curroncol29040216