Back to Search Start Over

Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma

Authors :
Lim Boon-Kiong
Chen Yeng
Hashim Onn H
Source :
Journal of Hematology & Oncology, Vol 2, Iss 1, p 37 (2009)
Publication Year :
2009
Publisher :
BMC, 2009.

Abstract

Abstract Background The general enhanced expression of α1-antichymotrypsin (ACT), clusterin (CLU), α1-antitrypsin (AAT), haptoglobin β-chain (HAP), and leucine rich glycoprotein (LRG) in the sera of patients with epithelial ovarian carcinoma (EOCa) was recently reported. In the present study, we compared the expression of the serum acute-phase proteins (APPs) in the patients according to their stages of cancer. Results Different altered stage correlative expression of the high abundance serum APPs was demonstrated in sera of the patients studied. While the expression of ACT, HAP and AAT appeared to demonstrate positive correlation with the three initial stages of the cancer, inverse correlation was apparently detected in the expression of LRG and CLU. For patients who were diagnosed with stage IV of the cancer, expression of the serum APPs did not conform to the altered progression changes. Conclusion Our results highlight the potential prognostic significance of selective high abundance serum APPs in patients with EOCa.

Details

Language :
English
ISSN :
17568722
Volume :
2
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Hematology & Oncology
Publication Type :
Academic Journal
Accession number :
edsdoj.3f7cad6ce5d140bdaf7eb07a115b5487
Document Type :
article
Full Text :
https://doi.org/10.1186/1756-8722-2-37