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A novel stem cell therapy for hepatitis B virus-related acute-on-chronic liver failure
- Source :
- Brazilian Journal of Medical and Biological Research, Vol 53, Iss 11 (2020)
- Publication Year :
- 2020
- Publisher :
- Associação Brasileira de Divulgação Científica, 2020.
-
Abstract
- The aim of this study was to propose a stem cell therapy for hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) based on plasma exchange (PE) for peripheral blood stem cell (PBSC) collection and examine its safety and efficacy. Sixty patients (n=20 in each group) were randomized to PE (PE alone), granulocyte colony-stimulating factor (G-CSF) (PE after G-CSF treatment), and PBSC transplantation (PBSCT) (G-CSF, PE, PBSC collection and hepatic artery injection) groups. Patients were followed-up for 24 weeks. Liver function and adverse events were recorded. Survival analysis was performed. PBSCT improved blood ammonia levels at 1 week (P
Details
- Language :
- English
- ISSN :
- 1414431X and 1414431x
- Volume :
- 53
- Issue :
- 11
- Database :
- Directory of Open Access Journals
- Journal :
- Brazilian Journal of Medical and Biological Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3f3b7e7228fc427b8e64447c010e7d05
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/1414-431x20209728