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Immunobiological Properties of Francisella tularensis 15/10 Strain with Deleted recA Gene
- Source :
- Проблемы особо опасных инфекций, Vol 0, Iss 4(110), Pp 65-67 (2011)
- Publication Year :
- 2011
- Publisher :
- Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”, 2011.
-
Abstract
- Deletion of recA gene in Francisella tularensis 15/10 genome leads to the increase in its sensitivity to ultraviolet irradiation, reduction of the homologous recombination capacity, and a slight decline of virulence for mice. Efficacy of Francisella tularensis 15/10ΔrecA reproduction within microphage-like cells, its resistance to normal rabbit serum, and protective properties on the mouse model of tularemia are the same as in original Francisella tularensis 15/10.
Details
- Language :
- Russian
- ISSN :
- 03701069 and 2658719X
- Issue :
- 4(110)
- Database :
- Directory of Open Access Journals
- Journal :
- Проблемы особо опасных инфекций
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.3eeddc45830c48d6bb4a5b9e4de400c1
- Document Type :
- article
- Full Text :
- https://doi.org/10.21055/0370-1069-2011-4(110)-65-67